2. Cell Cycle/DNA Damage TGF-beta/Smad Stem Cell/Wnt Cytoskeleton
  3. ROCK
  4. ROCK-IN-1

ROCK-IN-1 is a potent inhibitor of ROCK, with an IC50 of 1.2 nM for ROCK2.

For research use only. We do not sell to patients.

ROCK-IN-1 Chemical Structure

ROCK-IN-1 Chemical Structure

CAS No. : 934387-35-6

Size Price Stock Quantity
5 mg USD 350 In-stock
10 mg USD 600 In-stock
25 mg USD 1250 In-stock
50 mg USD 1950 In-stock
100 mg USD 3200 In-stock
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

ROCK-IN-1 Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE ROCK-IN-1

View All ROCK Isoform Specific Products:

View All Isoforms
ROCK ROCK1 ROCK2

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

ROCK-IN-1 is a potent inhibitor of ROCK, with an IC50 of 1.2 nM for ROCK2.

IC50 & Target[1]

ROCK2

1.2 nM (IC50)

Cellular Effect
Cell Line Type Value Description References
A7R5 EC50
6.1 nM
Compound: 1
Inhibition of ROCK in rat A7r5 cells assessed as inhibition of MLC phosphorylation by direct ELISA
Inhibition of ROCK in rat A7r5 cells assessed as inhibition of MLC phosphorylation by direct ELISA
[PMID: 24119557]
In Vitro

ROCK-IN-1 shows potent cellular efficacy, with an EC50 of 200 nM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ROCK-IN-1 Related Antibodies
Molecular Weight

335.37

Formula

C20H18FN3O
CAS No.
Appearance

Solid

Color

White to light yellow

SMILES

O=C(C1=CC(C2=CC=C(F)C=C2)=C(C(N)C)C=C1)NC3=CC=NC=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (298.18 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9818 mL 14.9089 mL 29.8178 mL
5 mM 0.5964 mL 2.9818 mL 5.9636 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.9818 mL 14.9089 mL 29.8178 mL 74.5445 mL
5 mM 0.5964 mL 2.9818 mL 5.9636 mL 14.9089 mL
10 mM 0.2982 mL 1.4909 mL 2.9818 mL 7.4545 mL
15 mM 0.1988 mL 0.9939 mL 1.9879 mL 4.9696 mL
20 mM 0.1491 mL 0.7454 mL 1.4909 mL 3.7272 mL
25 mM 0.1193 mL 0.5964 mL 1.1927 mL 2.9818 mL
30 mM 0.0994 mL 0.4970 mL 0.9939 mL 2.4848 mL
40 mM 0.0745 mL 0.3727 mL 0.7454 mL 1.8636 mL
50 mM 0.0596 mL 0.2982 mL 0.5964 mL 1.4909 mL
60 mM 0.0497 mL 0.2485 mL 0.4970 mL 1.2424 mL
80 mM 0.0373 mL 0.1864 mL 0.3727 mL 0.9318 mL
100 mM 0.0298 mL 0.1491 mL 0.2982 mL 0.7454 mL
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

ROCK-IN-1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ROCK-IN-1934387-35-6ROCKRho-associated protein kinaseRho-associated kinaseRho-kinaseROKInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
ROCK-IN-1
Cat. No.:
HY-U00351
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

English - EN (251 KB) Français - FR (251 KB) Deutsch - DE (251 KB) Norwegian - NO (251 KB) Español - ES (251 KB) Swedish - SV (251 KB)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.